Denise Delgado was born on May 13, 1981, in São Paulo, Brazil. From an early age, she showed remarkable communication skills, admired by both teachers and family.

She studied theater at the prestigious Macunaíma School of Drama in São Paulo and later pursued Social Communication at Anhembi Morumbi University. From ages 17 to 21, she modeled with the Elite agency, working for various Brazilian designers.

At 26, Denise moved to Europe—returning to modeling—and walked the runways in Milan, London, and Prague. While in Prague, she reignited her acting career, landing roles in commercials for global brands like Toyota, Pilsen Urquell, KB Bank, and Panadol.